Protease Inhibitors and Phosphatase Inhibitors
Medchemexpress LLC SB-277011 hydrochloride | 215804-67-4 | 99.59% | 475.02 | 100 MG
SB-277011 hydrochloride is a potent, selective, orally bioavailable, and brain-penetrant dopamine D3 receptor (D3R) antagonist. It exhibits high selectivity over other dopamine receptors, making it suitable for targeted research. The compound has an excellent pharmacokinetic profile in rats, demonstrating good oral bioavailability and brain penetration.
- Potent and selective D3 receptor antagonist
- Orally bioavailable and brain-penetrant
- Displays high selectivity over other dopamine receptors
- Reverses quinelorane effects in nucleus accumbens
- Reduces intravenous cocaine self-administration
- Inhibits basal and cocaine-enhanced locomotion
- Suitable for research use only
Cayman Chemical VEGFR2 KInase InhIbItr II 1mg
A reversible, cell-permeable inhibitor of VEGFR2’s kinase activity (IC50 = 70 nM); less potently inhibits PDGFRβ (IC50 = 920 nM); blocks the growth of human umbilical vein endothelial cells stimulated with either VEGF or PDGF (IC50s = 110 nM and 2 µM, respectively)
Abcam ML130, NOD1 inhibitor, 5MG
MW 287.34 Da, Purity >97%. Potent, selective NOD1 inhibitor (IC₅₀ = 560 nM). Inhibits NOD1-induced NF-κB activation in vitro. Cell-permeable.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Histone Demethylase KDM1/LSD1 Inhibitor Assay Kit.
Histone Demethylase KDM1/LSD1 Inhibitor Assay Kit.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical PAD2 InhIbItr Screeng as 96Wel
A convenient method for screening human PAD2 inhibitors
Cayman Chemical VEGFR2 KInase InhIbItr I 1mg
A potent, cell-permeable inhibitor of mouse VEGFR2 kinase (IC50 = 70 nM); has little or no effect against PDGFR, EGFR or IGF1R kinases (IC50 > 100 µM)
Cayman Chemical HAT InhIbItr II 1mg
A cell-permeable, selective inhibitor of the HAT p300 (IC50 = 5 µM)
CPC Scientific DNP-Pro-Tyr-Ala-Tyr-Trp-Met-Arg-OH (trifluoroacetate salt) 0.5MG
ONE-LETTER SEQUENCE: DNP-PYAYWMRMOLECULAR FORMULA: C54H65N13O14S1MOLECULAR WEIGHT:1152.25STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [158841-76-0], RESEARCH AREA: CancerREFERENCES: S. Netzel-Arnett, et al., Anal. Biochem. 195, 86 (1991)
CPC Scientific Boc-Asp(OBzl)-CMK 1MG
Inhibitor that penetrates cells and binds covalently to the active site of caspase-1 (ICE). At a concentration of 2.5 ?M, it blocks caspase-1-mediated processing of mature interleukin-1beta in a monocytic cell line by 85% without influencing tumor necrosis factor processing. ONE-LETTER SEQUENCE: Boc-D(OBzl)-CMKMOLECULAR FORMULA: C17H22Cl1NO5MOLECULAR WEIGHT:355.8STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [172702-58-8], RESEARCH AREA: ApoptosisREFERENCES: N.Boudreau et al., Science, 267, 891 (1995)
Medchemexpress LLC RIP1 kinase inhibitor 1 | 2095515-38-9 | 100.0% | 461.90 | 50 MG
RIP1 kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor (pKi=9.04). It strongly suppresses necroptotic cell death and phosphorylation of MLKL (pMLKL) in human colorectal adenocarcinoma HT-29 cells (necroptosis, IC50=2 nM; pMLKL, IC50=1.3 nM) as well as mouse L-cells NCTC 929 (necroptosis, IC50=15 nM; pMLKL, IC50=2.7 nM). This inhibitor is designed for high-speed applications.
- Highly potent and orally available
- Brain-penetrating RIP1 kinase inhibitor
- Strongly suppresses necroptotic cell death
- Inhibits phosphorylation of MLKL (pMLKL)
- Effective in human colorectal adenocarcinoma HT-29 cells
- Effective in mouse L-cells NCTC 929
Abcam LYS6K2, S6 kinase inhibitor, 5MG
MW 445.42 g/mol. Selective, cell-permeable S6 kinase inhibitor. Blocks phosphorylation of p70 ribosomal S6 kinase.
The product is subject to the following: Abcam Restricted Use Statement
Enzo Life Sciences DICA (25mg). CAS: 613665-26-2
Inhibitor of caspase-3 and caspase-7 binding to an allosteric site and not to the active site. Alternative name: 2-(2,4-Dichlorophenoxy)-N-(2-mercaptoethyl)acetamide. Purity: ≥98% (TLC). Appearance: White to off-white solid. Solubility: Soluble in methanol or DMSO. Long Term Storage: -20°C.
Cayman Chemical USP7-USP47 InhIbItr 1mg
A dual inhibitor of USP7 and USP47 (IC50s = 0.42 and 1 μM, respectively); selective for USP7 and USP47 over USP2, USP5, USP8, USP21, USP28, caspase-3, and cathepsin B (IC50s = >31.6 μM); inhibits the growth of HCT116 cells (EC50 = 7.6 μM)
Apexbio Technology LLC HIV-1 integrase strand transfer inhibitor 518048-05-0. MFCD10698872
HIV-1 integrase strand transfer inhibitor 518048-05-0. MFCD10698872
Selleck Chemical LLC USP25/28 inhibitor AZ1-5mg
AZ1 is a potent and noncompetitive dual Inhibitors of the ubiquitin-specific protease (USP) 25/28 with IC50s of 0.62 μM and 0.7 μM in Ub-RH110 assay,respectively.